Sunday, May 13, 2012


Researchers at the University of Pennsylvania School of Veterinary Medicine are evaluating a new vaccine for dogs that have been diagnosed with osteosarcoma.  Osteosarcoma (bone cancer) is most commonly seen in large and giant breeds of dogs. It is an aggressive cancer that frequently affects the long bones. Despite limb amputation and chemotherapy, many dogs die from the cancer that spreads to their lungs. Details of the study, including the benefits of enrollment, are available here

Mason Bone Cancer Study: Evaluation of a recombinant bacteria vaccine to treat bone cancer in dogs  


The purpose of this study is to determine whether a recombinant L. moncytogenes vaccine can elicit anti-tumor immunity and prolong survival in dogs with cancer of their long bones (appendicular osteosarcoma (OSA)).

If your dog has recently been diagnosed with bone cancer, or is currently undergoing
chemotherapy for bone cancer, he/she may be eligible for vaccination.

Enrollment criteria and baseline evaluation of patients

Researchers  are actively recruiting patients for a pilot study to determine the safety and efficacy of a new bacteria based vaccine to stimulate an immune response against osteosarcoma and prolong survival in dogs with bone cancer. Only those dogs with a histological diagnosis of osteosarcoma and who have undergone limb amputation and standard chemotherapy (4 doses of carboplatin) for the treatment of osteosarcoma will be eligible for inclusion in the study. In addition, only those patients whose tumors express the target antigen “Her-2/neu” will be eligible for inclusion in this study.

Up to 18 privately owned dogs with long bone cancer (appendicular OSA) and confirmed expression of Her2-neu will be enrolled.

If you are interested in learning more about this study, please contact the Principal Investigator,
Dr. Nicola Mason, at (215) 898-3996 or

Nicola Mason BVetMed PhD DACVIM
Pamela Cole Chair in Companion Animal Medicine 
Assistant Professor of Medicine 
University of Pennsylvania 
School of Veterinary Medicine
315 Hill Pavilion
380 South University Avenue
Philadelphia, PA 19104

Tel: (215) 898-3996
Fax: (215) 746-2295

Cynthia M. Otto DVM, PhD, DACVECC
Associate Professor Critical Care
Director Penn Vet Working Dog Center
University of Pennsylvania
School of Veterinary Medicine
3900 Delancey St.
Philadelphia, PA 19104-6010

office (215) 898-3390
fax (215) 573-6050

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